UMCUniversity of Massachusetts Chan Medical School · Biology
Erythropoiesis and Ribosome Dynamics Lab
Merav Socolovsky · Worcester, Massachusetts
Research Focus
Dr. Merav Socolovsky's lab focuses on understanding the process of red blood cell formation, called erythropoiesis. The lab investigates how specific signaling pathways, specifically those involving EpoR and Stat5, regulate protein synthesis and ribosome production during the critical stages of erythroid cell development. This research aims to uncover the connections between cell cycle duration, cell growth, and the quality of DNA replication, which could have important implications for both developmental biology and diseases like anemia and cancer.
erythropoiesisribosome biogenesisprotein synthesisEpoRStat5DNA damage responsered blood cell developmentcell cyclegenomic instability
Research Aims
3AIM 01Investigate the EpoR/Stat5-induced spike in ribosome biogenesis and protein synthesis during erythroid development.
AIM 02Determine the relationship between cell cycle duration, protein synthesis, and cell size.
AIM 03Examine the DNA damage response in fast-cycling erythroblasts compared to slower-cycling progenitors.
Skills the Lab Values
PCRcell culturemouse modelsRNA sequencingWestern blotflow cytometrygenome editingbioinformaticsmicroscopy
Output against the department
Publications91bottom 30% of dept.719th of 1,033
this lab
most publishedleast published
Citations5.9kbottom 43% of dept.591st of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.