Stanford University · Biomedical EngineeringLaboratory for Spatial RNA Dynamics
Lei Stanley Qi · Stanford, California
Research Focus
Dr. Lei Stanley Qi's lab at Stanford University focuses on understanding how the spatial organization of mRNA in cells affects both normal cellular functions and disease mechanisms. The team develops new technologies to track and manipulate the localization of mRNAs within cells, particularly in neurons, to investigate their roles in processes like axon development and synaptic activity. By studying how mislocalized mRNA contributes to diseases such as ALS and spinal muscular atrophy, the lab aims to uncover innovative therapeutic strategies.
spatial RNA organizationCRISPRmRNA localizationaxon guidanceneurodegenerative diseaseshigh-throughput imagingmachine learningRNA dynamicslive-cell imagingRNA tracking
Research Aims
5AIM 01Develop technologies for tracking mRNA localization in live cells.
AIM 02Explore the regulatory mechanisms of mRNA localization in primary neurons.
AIM 03Investigate the relationship between mRNA organization and neurological diseases.
AIM 04Use the new framework to identify therapeutic strategies for spinal muscular atrophy.
AIM 05Create an atlas of spatial RNA organization for various cell types.
Skills the Lab Values
RNA Live-Cell Fluorescent In Situ Hybridization (RNA-LiveFISH)CRISPR-mediated transcript organization (CRISPR-TO)high-throughput sequencingcomputational analysisdeep learningcell culture techniquesmicroscopybioinformaticsRNA isolation and analysisdata visualization
Output against the department
Publications287top 33% of dept.197th of 595
this lab
most publishedleast published
Citations34ktop 7% of dept.39th of 595
this lab
most citedleast cited
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