UTHThe University of Texas Health Science Center at Houston · Neuroscience
Mosher Lab
John Compton Mosher · Houston, Texas
Research Focus
Dr. John Compton Mosher's lab focuses on developing a new digital biomarker for the early detection of Alzheimer's disease. They aim to create a noninvasive, low-cost testing method using advanced EEG technology to identify key brain signals associated with Alzheimer's. This innovative approach could revolutionize how the disease is screened, making it easier to catch in its early stages before severe symptoms appear.
Alzheimer's diseasedigital biomarkersEEGearly detectionmachine learningepileptogenic activityfunctional brain networksambulatory testingnoninvasive screening
Research Aims
3AIM 01Identify specific features of epileptogenic activity that predict conversion from mild cognitive impairment to Alzheimer's disease.
AIM 02Design a digital biomarker that uses both epileptogenic activity and functional brain networks to predict Alzheimer's disease progression.
AIM 03Extend the digital biomarker to utilize ambulatory EEG with dry electrode technology.
Skills the Lab Values
electroencephalography (EEG)machine learningdata analysissignal processingneuroimaging techniquesdry-electrode technologygraph theoryclinical data collectiondeep learning model development
Output against the department
Publications206top 36% of dept.239th of 671
this lab
most publishedleast published
Citations15ktop 27% of dept.183rd of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.