University of Pittsburgh-Pittsburgh Campus · PharmacologyLiver Development and Signaling Laboratory
Satdarshan Singh Monga · Pittsburgh, Pennsylvania
Research Focus
Dr. Monga's lab at the University of Pittsburgh studies how the Wnt-Beta-catenin signaling pathway influences liver development and functions. Their research explores how this signaling regulates liver cell growth and the overall organization of liver cells in different zones. By understanding these processes, the team aims to uncover new insights that could inform treatments for liver diseases.
Wnt-Beta-cateninliver developmentmetabolic zonationhepatocytegene expressionhypoxiatranscription regulationzone-specific analysis
Research Aims
3AIM 01Investigate the role of Wnt in regulating beta-catenin during liver development.
AIM 02Characterize gene expression differences in liver zones based on Wnt signaling.
AIM 03Explore the regulatory mechanisms of hypoxia on Wnt expression in liver endothelial cells.
Skills the Lab Values
HEK cell cultureRNA sequencingATAC-seqChIP-seqmouse modelsgene knockout techniquesbioinformaticstranscriptomic analysisfunctional genomics
Output against the department
Publications573top 8% of dept.39th of 462
this lab
most publishedleast published
Citations18ktop 21% of dept.99th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.