Brown University · PharmacologySplicing and Genomics Research Unit
William G Fairbrother · Providence, Rhode Island
Research Focus
Dr. William G. Fairbrother's lab focuses on understanding splicing defects in human genes, particularly how specific mutations affect the way RNA is processed. By analyzing large genomic data sets, the lab aims to identify mutations that can lead to various diseases. The team is also exploring ways to correct these mutations using innovative techniques, which could have significant implications for developing targeted therapies.
splicinggenomicsRNA processingdisease mutationsgenome sequencing
Research Aims
4AIM 01Identify splicing mutations in human genes using large-scale sequencing data.
AIM 02Map the distribution of splicing mutations across the genome.
AIM 03Explore mechanisms of splice site selection in RNA processing.
AIM 04Investigate the potential of antisense oligonucleotides to correct splicing defects.
Skills the Lab Values
RNA splicing analysisgenomic sequencingbioinformaticsantibody generationcell line culture
Output against the department
Publications89bottom 21% of dept.364th of 462
this lab
most publishedleast published
Citations4.8kbottom 35% of dept.299th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.