University at Albany · BiologyBegley Toxicology Lab
Thomas J Begley · Albany, New York
Research Focus
Dr. Thomas J. Begley's lab at SUNY Albany focuses on understanding how genetic and environmental factors interact to influence cellular responses to toxic substances, particularly naphthalene found in wood smoke. They explore how modifications to RNA and DNA impact gene expression and responses to cell stress. By using techniques in molecular biology and animal models, the lab aims to uncover novel strategies to reduce the harmful effects of air pollutants on human health.
epitranscriptomeepigeneticstoxicologynaphthalenelung inflammationreactive oxygen speciesgene expressioncell stressfirefighter health
Research Aims
4AIM 01Define the interplay between the epitranscriptome and epigenome in response to toxins.
AIM 02Investigate the role of tRNA modifications in regulating gene expression during cell stress.
AIM 03Test how exposure to naphthalene affects cellular responses in human cells and mice.
AIM 04Develop potential strategies to mitigate the toxic effects of wood smoke exposure.
Skills the Lab Values
RNA sequencingtRNA modification analysiscell culture techniquesmouse modelsreactive oxygen species measurementmethylation profilingproteomicsbronchoalveolar lavagedata analysis with bioinformatics tools
Output against the department
Publications7bottom 1% of dept.1,023rd of 1,033
this lab
most publishedleast published
Citations10ktop 37% of dept.387th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.