University of Connecticut · BiologyYue Lab
Lixia Yue · Storrs, Connecticut
Research Focus
Dr. Lixia Yue's lab at the University of Connecticut focuses on understanding the mechanisms behind cardiac fibrosis, a condition that contributes to various heart diseases. By investigating a specific ion channel called TRPM7 in cardiac fibroblasts, the lab aims to explore therapeutic targets for improving treatment options for heart failure. The research combines molecular biology with advanced animal models to uncover how signaling pathways influence heart health.
TRPM7cardiac fibrosisfibroblastsheart diseasecalcium signalingtherapeutic targetsTGF-betamolecular biologyheart failure
Research Aims
5AIM 01Investigate the role of TRPM7 channel function in cardiac fibrogenesis.
AIM 02Determine the role of TRPM7 kinase function in modulating cardiac fibrosis.
AIM 03Identify fibroblast-specific therapeutic targets for fibrogenesis.
AIM 04Explore the protective effects of TRPM7 deletion in heart failure models.
AIM 05Provide insights into innovative therapies for pressure overload and ischemic injuries related to heart disease.
Skills the Lab Values
molecular biologymouse transgenic modelspatch-clamp techniquesCa2+ imagingbiochemical assaysknockout mouse modelsin vitro culture methodsdata analysisinterdisciplinary research methods
Output against the department
Publications136bottom 49% of dept.526th of 1,033
this lab
most publishedleast published
Citations10ktop 36% of dept.370th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.