University of Texas Southwestern Medical Center · BiologyCenter for Clear Cell Renal Research
Qing Zhang · Dallas, Texas
Research Focus
Dr. Qing Zhang's lab at UT Southwestern Medical Center focuses on understanding clear cell renal cell carcinoma (ccRCC), a highly aggressive form of kidney cancer that often metastasizes to the lungs. The lab uses advanced techniques like CRISPR screening and RNA sequencing to uncover the molecular mechanisms behind this cancer's progression and treatment resistance. Their research aims to identify new therapeutic targets that could improve survival outcomes for patients with metastatic kidney cancer.
ccRCCCRISPRlung metastasisVHLm6A modificationtumor growthkidney cancergene expressiontherapeutic targetstumor suppressor
Research Aims
4AIM 01Characterize the role of Hepatic Leukemia Factor (HLF) in ccRCC lung metastasis.
AIM 02Investigate the molecular mechanism by which HLF influences ccRCC migration.
AIM 03Determine how VHL regulates m6A modifications in kidney cancer.
AIM 04Examine the functional implications of VHL-m6A signaling in ccRCC tumorigenesis.
Skills the Lab Values
CRISPR screeningRNA sequencingChIP-Seqcell culturemouse modelspatient-derived xenograftsmolecular cloninggenomic editingbiostatisticsdata analysis
Output against the department
Publications1,031top 1% of dept.15th of 1,033
this lab
most publishedleast published
Citations23ktop 17% of dept.171st of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.