Yale University · BiologyVesicle Dynamics and Signaling Unit
Sathish K Ramakrishnan · New Haven, Connecticut
Research Focus
Dr. Sathish K. Ramakrishnan's lab at Yale University focuses on understanding how large dense-core vesicles (LDCVs) release important signals like hormones in our body. Their work explores how different types of vesicles behave differently during this release process, which is crucial for many functions such as metabolism and mood regulation. By using advanced technologies to observe and track these vesicles, the lab aims to uncover insights that could lead to better treatments for various diseases, including diabetes and mental health disorders.
vesicle releasehormonal signalingcellular biologymembrane biophysicsdisease mechanismsneurodegenerative diseasesmetabolic disordersexocytosiscalcium signaling
Research Aims
5AIM 01Investigate the different modes of LDCV release and their physiological implications.
AIM 02Explore the role of calcium signaling and lipid dynamics during vesicle fusion.
AIM 03Develop next-generation technology platforms for studying ultrafast fusion kinetics.
AIM 04Examine how vesicle heterogeneity influences fusion pore kinetics in LDCVs.
AIM 05Link vesicular release mechanisms to metabolic and psychological disorders.
Skills the Lab Values
cell cultureimmunofluorescencelive-cell imagingbiophysical assaysmolecular cloningcalcium imagingmicroscopysingle-molecule trackinglipid membrane technologydata analysis
Output against the department
Publications62bottom 16% of dept.864th of 1,033
this lab
most publishedleast published
Citations1.2kbottom 6% of dept.967th of 1,033
this lab
most citedleast cited
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