UWMUniversity of Wisconsin-Madison · Chemistry
Protein Dynamics Lab
Samuel H. Gellman · Madison, Wisconsin
Research Focus
Dr. Samuel H. Gellman’s lab at the University of Wisconsin-Madison explores the roles of proteins and peptides in cellular processes, particularly how they influence signaling pathways and the formation of membraneless organelles. Their research has applications in understanding diseases like diabetes and neurodegenerative disorders, as they investigate how molecular interactions can affect receptor functions and cellular organization. This work could lead to new therapeutic strategies targeting these critical biological mechanisms.
G protein-coupled receptorsliquid-liquid phase separationcell signalingneurodegenerative diseasespeptide designmembraneless organellessignal transductionproteinstherapeutic strategiesbiological processes
Research Aims
5AIM 01Investigate the mechanisms of signal transduction by G protein-coupled receptors.
AIM 02Explore the effects of peptide conformations on receptor binding and signaling outcomes.
AIM 03Develop models of liquid-liquid phase separation mediated by proteins and peptides.
AIM 04Evaluate the role of noncovalent interactions in the dynamics of membrane-less organelles.
AIM 05Identify therapeutic potential in therapeutics targeting dysregulated protein processes.
Skills the Lab Values
chemical synthesiscell culture techniquesprotein modelingpeptide synthesisWestern blottingfluorescence microscopymolecular biology techniquesbioinformaticsdata analysiscell surface receptor studies
Output against the department
Publications671top 10% of dept.21st of 216
this lab
most publishedleast published
Citations42ktop 8% of dept.17th of 216
this lab
most citedleast cited
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