Boston University · NeuroscienceNeurodegeneration and Head Impact Research Lab
Ann C. Mckee · Boston, Massachusetts
Research Focus
Dr. Ann C. McKee's lab at Boston University focuses on understanding the long-term effects of repetitive head impacts, such as those experienced in sports and military service. The research aims to reveal how these impacts contribute to neurodegenerative diseases like Alzheimer's and chronic traumatic encephalopathy (CTE) over a person's lifespan, particularly emphasizing early-life changes. By studying brain tissue from various age groups, the lab seeks to identify early biomarkers and potential therapeutic targets for these conditions.
head impactsneurodegenerationAlzheimer's diseasechronic traumatic encephalopathybrain healthyoung athletesneuropathologyimaging technologiesbiomarkers
Research Aims
3AIM 01Determine clinical and pathological consequences of repetitive head impacts in young adults aged 18-39 years.
AIM 02Examine the impact of repetitive head impacts during mid-life (ages 40-59 years).
AIM 03Investigate the long-term effects of repetitive head impacts in late life (ages 60-79 years).
Skills the Lab Values
multiplex immunofluorescenceRNA sequencingspatial transcriptomicsex vivo MRImachine learningpathological analysisdigital quantitation3D imagingclinical assessment
Output against the department
Publications505top 11% of dept.72nd of 671
this lab
most publishedleast published
Citations57ktop 6% of dept.39th of 671
this lab
most citedleast cited
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