New York University · BiologyLafaille Lab
Juan Lafaille · New York, New York
Research Focus
Dr. Juan Lafaille's lab at New York University focuses on understanding how specific types of immune cells, called border-associated macrophages (BAMs), maintain healthy blood vessels in the brain. This research is particularly relevant to diseases like Alzheimer's, where the buildup of amyloid proteins can disrupt vascular function. By studying unique mouse models, the lab aims to uncover the role of BAMs in preventing these complications and advancing our knowledge of brain health, aging, and neurodegenerative diseases.
Alzheimer's Diseasecerebral amyloid angiopathymacrophagesbrain healthage-related cognitive decline
Research Aims
4AIM 01Investigate the role of border-associated macrophages in maintaining brain vasculature.
AIM 02Determine how aging affects the function of macrophages in the brain.
AIM 03Use animal models to assess the impact of macrophage dysfunction on amyloid deposition and cognitive impairment.
AIM 04Explore the genetic mechanisms regulating macrophages in cerebral amyloid angiopathy.
Skills the Lab Values
mouse modelsflow cytometrygenetic engineeringimmunohistochemistrycell culture
Output against the department
Publications117bottom 42% of dept.601st of 1,033
this lab
most publishedleast published
Citations22ktop 17% of dept.179th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.