Harvard University · Microbiology & ImmunologyChlamydia Immunology Research Lab
Michael N Starnbach · Cambridge, Massachusetts
Research Focus
Dr. Michael Starnbach's lab at Harvard Medical School focuses on understanding how the immune system, specifically CD8+ T cells, responds to infections caused by the bacterium Chlamydia trachomatis. The lab aims to uncover why these T cells are unable to form long-lasting memory after primary infection, which leads to repeated infections and potential infertility in affected individuals. Their research also explores new vaccine strategies to enhance immune response and protection against this significant public health issue.
ChlamydiaCD8 T cellsadaptive immunityvaccine developmentreproductive healthimmunologychronic infectionsmemory T cellsnanoparticles
Research Aims
4AIM 01Understand the mechanisms that inhibit CD8+ T cell memory during Chlamydia infection.
AIM 02Develop methods to enhance CD8+ T cell memory in response to infection.
AIM 03Identify and test vaccine formulations that stimulate protective CD8+ T cells.
AIM 04Evaluate the enhancement of vaccine-mediated CD4+ T cell immunity.
Skills the Lab Values
cell culturemice modelsflow cytometryimmunological assaysvaccine formulationnanoparticle technologyT cell activationprotein assaysexperimental design
Output against the department
Publications106bottom 38% of dept.299th of 486
this lab
most publishedleast published
Citations6.0kbottom 45% of dept.269th of 486
this lab
most citedleast cited
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