University of California-San Francisco · PharmacologyGalonic Ribosome Lab
Danica Galonic Fujimori · San Francisco, California
Research Focus
Dr. Danica Galonic Fujimori's lab focuses on understanding how certain bacteria develop resistance to antibiotics through modifications to their ribosomes. This research is important because it helps us combat the growing problem of antibiotic resistance, which affects public health and treatment options. The lab uses advanced techniques to study the enzymes involved in this process and aims to uncover new strategies to tackle bacterial infections.
antibiotic resistanceribosomemethylationCfr enzymedirected evolutioncryogenic electron microscopygene expressionbacterial infectionspublic health
Research Aims
5AIM 01Investigate how methylation by Cfr enzymes confers antibiotic resistance.
AIM 02Characterize the structural basis of ribosome modifications in bacteria.
AIM 03Explore the role of antibiotic-induced ribosome stalling in regulating resistance genes.
AIM 04Develop variants of Cfr enzymes to improve our understanding of ribosome methylation.
AIM 05Identify new substrates and functions of the diverse Cfr enzyme family.
Skills the Lab Values
RNA sequencingcryo-electron microscopyprotein purificationbacterial culturemutagenesisDNA sequencingin vitro assaysmolecular cloningbiochemical assays
Output against the department
Publications84bottom 19% of dept.374th of 462
this lab
most publishedleast published
Citations9.1ktop 42% of dept.193rd of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.