University of California-San Francisco · PharmacologyProtein Design and Engineering Lab
Tanja Kortemme · San Francisco, California
Research Focus
Dr. Tanja Kortemme's lab at UCSF focuses on designing and engineering proteins to enhance their biological functions and correct errors in cellular processes. They use computational methods to create new proteins that can respond to signals within cells and investigate how existing proteins operate within cellular networks. This research not only aims to improve our understanding of biology but also to develop new strategies for therapeutic applications in medicine and biotechnology.
protein engineeringcomputational designbiological error correctioncellular regulationallosterydiagnosticsbiotechnologysynthetic biologymetabolic engineering
Research Aims
5AIM 01Develop generalizable strategies for biological error correction.
AIM 02Engineer proteins to sense and respond to new signals.
AIM 03Investigate the mechanisms of allostery in regulatory proteins.
AIM 04Integrate de novo designed proteins into modular biological systems.
AIM 05Explore cellular responses to perturbations in protein function.
Skills the Lab Values
protein designcomputational modelingmolecular cloningmutagenesis techniquesprotein expressionhigh-throughput assaysbiophysical analysiscell culturesystems biology
Output against the department
Publications209top 42% of dept.192nd of 462
this lab
most publishedleast published
Citations28ktop 10% of dept.46th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.