Yale University · Microbiology & ImmunologyJoshi Immunology Lab
Nikhil Joshi · New Haven, Connecticut
Research Focus
Dr. Nikhil Joshi's lab studies how immune cells called CD8 T cells develop and respond to tumors, particularly in lung cancer. His research focuses on the tumor-draining lymph node, where these cells are maintained, and investigates the signals that can either enhance their ability to fight tumors or lead to their dysfunction. They use advanced techniques to manipulate the immune cells genetically and analyze their behavior at the single-cell level.
lung cancerCD8 T cellstumor microenvironmentimmunotherapyT cell differentiationPD-1cytotoxic T lymphocytesimmune signalingCRISPR
Research Aims
3AIM 01Investigate mechanisms controlling CD8 T cell differentiation in the tumor-draining lymph node.
AIM 02Determine the impact of IL-21 and BATF signaling on TPEX effector CD8 T cell transitions.
AIM 03Evaluate the role of KLF2 in maintaining T cell stemness and its interaction with TCR signals.
Skills the Lab Values
flow cytometrycell cultureCRISPR genetic engineeringsingle-cell RNA sequencingimmunofluorescencemouse modelsRNA extractionWestern blotdata analysis using Python
Output against the department
Publications117bottom 44% of dept.269th of 486
this lab
most publishedleast published
Citations7.5ktop 47% of dept.228th of 486
this lab
most citedleast cited
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