Texas A&M University-College Station · GeneticsLaboratory of Cancer Immunotherapy and Epigenetics
Roderick H Dashwood · College Station, Texas
Research Focus
Dr. Roderick H. Dashwood's lab focuses on cancer research, specifically targeting immune responses in patients with Familial Adenomatous Polyposis (FAP), a genetic condition that increases the risk of colorectal cancer. The lab investigates how certain drugs can upregulate the Major Histocompatibility Complex (MHC) on cancer cells to enhance the immune system's ability to recognize and attack tumors. By combining traditional cancer drugs with new epigenetic therapies, they aim to improve immune responses before cancer develops, thereby offering new interventions for at-risk patients.
epigeneticscancer immunotherapyMHCFamilial Adenomatous Polyposisdrug repurposingimmune evasionT cell recruitmentpreclinical modelscolon cancertherapeutic targeting
Research Aims
5AIM 01Determine the impact of drug combinations on MHC-I/II expression in cancer and normal cells.
AIM 02Investigate immune cell interactions with cancer cells in co-culture systems.
AIM 03Assess the therapeutic efficacy and safety of new drug combinations in preclinical models.
AIM 04Examine patient biopsies for MHC-related epigenetic changes that correlate with immune response.
AIM 05Analyze drug effects on cancer organoids to develop precision therapies.
Skills the Lab Values
cell cultureimmunoblottingRT-qPCRmouse modelsbiopsy techniquesdrug administrationflow cytometrybiomarker analysispeptidomicsco-culture techniques
Output against the department
Publications313top 27% of dept.70th of 259
this lab
most publishedleast published
Citations15ktop 37% of dept.97th of 259
this lab
most citedleast cited
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