University of Michigan-Ann Arbor · BiochemistryAutophagy Research Laboratory
Daniel J. Klionsky · Ann Arbor, Michigan
Research Focus
Dr. Daniel J. Klionsky's lab at the University of Michigan focuses on understanding autophagy, a crucial cellular process for maintaining health and preventing disease. They explore how this process is regulated and its implications for conditions like cancer, heart disease, and neurodegeneration. By studying yeast models, the lab aims to uncover the molecular mechanisms and proteins involved in autophagy, providing insights that could lead to new therapeutic strategies.
autophagycell homeostasisdisease modulationyeast modelscellular mechanismstherapeutic interventionsprotein regulation
Research Aims
3AIM 01Investigate the structure and function of autophagy-related proteins.
AIM 02Define regulatory controls that initiate autophagy and maintain its levels.
AIM 03Understand how specific mutations in autophagy lead to human diseases.
Skills the Lab Values
yeast culturemolecular geneticsbiochemical assaysprotein analysiscell biologymicroscopyDNA manipulationbioinformaticsdata interpretation
Output against the department
Publications879top 3% of dept.12th of 402
this lab
most publishedleast published
Citations131ktop 1% of dept.5th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.