Brown University · Microbiology & ImmunologyReproductive Immunology Lab
Lalit K Beura · Providence, Rhode Island
Research Focus
Dr. Lalit K Beura's lab at Brown University focuses on understanding how specific immune cells called CD8 T lymphocytes protect the female reproductive tract from viral infections. By investigating how these cells develop and maintain their protective functions, the lab aims to improve strategies for vaccine development against viral diseases affecting this important area of the body. The research combines advanced techniques like single-cell RNA sequencing and in vitro organoid systems to explore the complex biology of immune responses.
CD8 T lymphocytesfemale reproductive tractimmune responsevaccine developmentviral infectionsresident memory T cellsTGF-beta signalingcellular differentiationinflammation
Research Aims
4AIM 01Understand the diversity and differentiation processes of CD8 T cell subsets in the reproductive mucosa.
AIM 02Investigate the role of type-1 interferon in generating protective CD8 T cell populations.
AIM 03Examine how vaginal microbial dysbiosis affects the differentiation of T cell subsets.
AIM 04Identify the sources and timing of TGF-beta signals necessary for maintaining protective T cells.
Skills the Lab Values
single-cell RNA sequencingin vivo infection modelsin vitro organoid systemsflow cytometrymouse modelsimmunohistochemistryantibody-based techniquescell culturegene editing
Output against the department
Publications80bottom 26% of dept.359th of 486
this lab
most publishedleast published
Citations9.0ktop 40% of dept.196th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.