New York University · BiologyDynlacht Ciliogenesis Lab
Brian D Dynlacht · New York, New York
Research Focus
Dr. Brian Dynlacht's lab at NYU School of Medicine focuses on understanding how primary cilia, tiny structures on the surface of cells, are assembled and disassembled. These cilia are crucial for sensing signals from the environment and play important roles in cell growth and division. The lab studies specific proteins that help configure cilia and other cellular structures, which can have implications in developmental defects and cancer. By uncovering the connections between protein functions and cellular processes, the lab aims to advance knowledge in cell biology and potential disease mechanisms.
primary ciliatubulinciliogenesiscell cycleorganellesprotein functionbiochemistrycell biologycancertubulin modifications
Research Aims
2AIM 01Investigate how the TPG complex regulates tubulin modifications, particularly glutamylation, in cilium dynamics.
AIM 02Determine the role of the TPG complex in Golgi assembly using biochemical and cell biology approaches.
Skills the Lab Values
cell culturebiochemical assaysprotein purificationgene knockout techniquesmicroscopybiochemical reconstitutionstructural modelingflow cytometrytubulin modification analysis
Output against the department
Publications140top 49% of dept.505th of 1,033
this lab
most publishedleast published
Citations29ktop 12% of dept.126th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.