University of Washington-Seattle Campus · GeneticsTumor Dynamics Lab
Alison F Feder · Seattle, Washington
Research Focus
Dr. Alison F Feder's lab focuses on understanding the evolution of solid tumors and their progression to metastasis. By developing innovative methods that combine genetics and computational modeling, the lab aims to reconstruct the historical growth of tumors and predict their future behavior. This research is crucial for creating effective diagnostic tools and improving cancer treatment by providing insights into tumor dynamics and the identification of critical mutations.
tumor evolutionmetastasisphylodynamicssingle cell sequencingcancer progressiondiagnostic toolsphylogenetic modelingtumor heterogeneitydriver mutations
Research Aims
5AIM 01Develop methodologies to reconstruct the evolutionary dynamics of solid tumors.
AIM 02Predict which tumor cellular lineages are likely to progress towards poor clinical outcomes.
AIM 03Utilize single cell DNA sequencing data to enhance understanding of cancer evolution.
AIM 04Create calibrated timelines for tumor initiation and clonal subpopulations.
AIM 05Identify critical driver mutations and understand their role in tumorigenesis.
Skills the Lab Values
DNA sequencingcomputational modelingdata analysisgenetic analysisphylogenetic analysiscancer genomicsbioinformaticsstatistical modelingcell culture
Output against the department
Publications39bottom 7% of dept.241st of 259
this lab
most publishedleast published
Citations912bottom 3% of dept.250th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.