University of Pittsburgh-Pittsburgh Campus · PharmacologyCardiovascular Health and Nutrition Lab
Marco Fazzari · Pittsburgh, Pennsylvania
Research Focus
Dr. Marco Fazzari's lab focuses on understanding how certain dietary components can help treat cardiovascular diseases. They study dietary nitrates and fatty acids to find new ways to reduce inflammation and promote heart health. Their research aims to develop safe therapies that can improve cardiovascular function and potentially lower the risk of heart disease.
cardiovascular diseasenitratesfatty acidsinflammationdietary interventionsvasodilationpost-translational modificationcGMP signaling
Research Aims
5AIM 01Investigate the biochemical formation of nitro-nitrate fatty acid derivatives.
AIM 02Define the pharmacokinetics of dietary-derived nitro-fatty acids.
AIM 03Assess cardiovascular responses to nitro-nitrate fatty acids in vitro and in vivo.
AIM 04Explore the mechanisms of cGMP-dependent and cGMP-independent signaling in cardiovascular health.
AIM 05Develop novel therapeutic strategies targeting inflammation in cardiovascular disease.
Skills the Lab Values
organic synthesisin vitro assayscell cultureanimal modelspharmacokineticsgene expression analysisbiochemical assaysdata analysisdietary component analysis
Output against the department
Publications72bottom 15% of dept.390th of 462
this lab
most publishedleast published
Citations1.7kbottom 10% of dept.418th of 462
this lab
most citedleast cited
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