Dartmouth College · ChemistryKull Lab
Fredrick Jon Kull · Hanover, New Hampshire
Research Focus
In Fredrick Jon Kull's lab at Dartmouth College, researchers study how certain bacteria can cause disease and how they can be inhibited. They focus on a group of proteins that regulate virulence genes in bacteria, which are vital for pathogenicity. By understanding these proteins' structure and function, the lab aims to discover new ways to combat bacterial infections.
bacterial pathogensvirulence regulationprotein structuregene expressionsmall molecule inhibitorspolypeptide inhibitorsmicrobiologybiochemistrytherapeutic strategies
Research Aims
3AIM 01Investigate the structural mechanism of how ligand binding affects protein dimerization and activity.
AIM 02Assess if related proteins are regulated similarly to the main target protein.
AIM 03Characterize how polypeptide inhibitors affect protein function compared to small molecule inhibitors.
Skills the Lab Values
structural biology techniquesprotein purificationmolecular cloningDNA binding assayscell culturebiochemical assaysmicroscopygel electrophoresisRNA extraction
Output against the department
Publications122bottom 26% of dept.158th of 216
this lab
most publishedleast published
Citations3.9kbottom 27% of dept.158th of 216
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.