Johns Hopkins University · Biomedical EngineeringNeurogenesis and Development Lab
Reza Kalhor · Baltimore, Maryland
Research Focus
Professor Reza Kalhor's research lab focuses on understanding how genetic changes affect brain development and lead to conditions like autism. By using advanced genomic techniques, they aim to create detailed maps of how brain cells develop from their early stages. This knowledge could help uncover the origins of developmental disorders and improve public health outcomes.
neurogenesisautismgenomic barcodingcell lineagegenetic perturbationsmouse modelsembryonic developmentcell differentiationpublic health
Research Aims
3AIM 01Establish high-resolution lineage recording in combinatorial and cumulative barcodes in cell genomes.
AIM 02Develop in situ single-cell barcode and identity readouts from mouse tissues.
AIM 03Investigate the effects of Chd8 haploinsufficiency on mouse brain development using lineage reconstruction.
Skills the Lab Values
high-throughput sequencinggenomic barcodingmouse modelsin situ sequencingDNA mutagenesiscell culturebioinformaticstissue sectioningdata analysis
Output against the department
Publications66bottom 8% of dept.545th of 595
this lab
most publishedleast published
Citations4.0kbottom 31% of dept.408th of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.