Michigan State University · PharmacologyAlzheimer's Therapeutics Research Unit
Kin Sing Stephen Lee · East Lansing, Michigan
Research Focus
Dr. Kin Sing Stephen Lee's research lab focuses on developing new treatments for Alzheimer's disease, which is a growing concern as the population ages. The lab specifically aims to create inhibitors for an enzyme called soluble epoxide hydrolase (sEH), which may alleviate symptoms of the disease. Researchers will investigate how to improve the efficacy of these inhibitors to ensure they effectively reach the brain and work optimally.
Alzheimer's diseasesEH inhibitorsdrug developmentCNS penetrationneuroinflammationtauopathyamyloidosispharmacokineticstherapeutic targets
Research Aims
4AIM 01Develop novel sEH inhibitors for Alzheimer's disease treatment.
AIM 02Investigate how the structure of inhibitors affects their ability to penetrate the blood-brain barrier.
AIM 03Optimize sEH inhibitors for improved pharmacokinetic properties and CNS exposure.
AIM 04Test the efficacy of optimized inhibitors in mouse and rat models of Alzheimer's disease.
Skills the Lab Values
in vitro pharmacokinetic assaysdrug designstructure-activity relationship studiesanimal model testingoral dosing methodologiesdata analysis in pharmacologylead optimizationenzyme inhibition techniques
Output against the department
Publications119bottom 34% of dept.304th of 462
this lab
most publishedleast published
Citations3.1kbottom 24% of dept.352nd of 462
this lab
most citedleast cited
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