University of North Carolina at Chapel Hill · BiochemistryThe KRAS Initiative
Sharon L Campbell · Chapel Hill, North Carolina
Research Focus
Dr. Sharon L. Campbell's research lab at the University of North Carolina focuses on understanding the molecular mechanisms by which mutated proteins contribute to cancer, particularly through the study of KRAS, a protein often mutated in lung cancers. The lab employs a variety of techniques to explore how these mutations can be targeted with innovative drugs, enhancing therapeutic strategies and potentially improving patient outcomes. Additionally, the lab delves into the roles of specific cell adhesion proteins in regulating cellular movement and stability, aiming to uncover pathways that could lead to new treatments for associated diseases.
KRAScancerdrug discoveryG-proteinscell adhesionoxidationprotein kineticscell motilitytherapeutic interventions
Research Aims
4AIM 01Investigate the kinetic mechanisms of KRASG12C inhibitors.
AIM 02Assess the impact of redox modifications on KRASG12C and inhibitor efficacy.
AIM 03Explore the activation of G-proteins through unconventional allosteric networks.
AIM 04Examine the role of vinculin and metavinculin in cell adhesion and motility.
Skills the Lab Values
fl fluorescence-based assayscell culturemolecular dynamics simulationskinetic characterization techniquesbioinformaticsWestern blottingCRISPR gene editing3D protein modelingcell signaling analysis
Output against the department
Publications263top 27% of dept.107th of 402
this lab
most publishedleast published
Citations13ktop 39% of dept.158th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.