UTHThe University of Texas Health Science Center at Houston · Biochemistry
Enhancer RNA and Alzheimer's Research Unit
Wenbo Li · Houston, Texas
Research Focus
Dr. Wenbo Li's lab at the University of Texas Health Science Center focuses on understanding the role of enhancer RNAs in regulating brain genes and their connections to Alzheimer's disease. By investigating how these noncoding RNAs function and affect gene expression, the lab aims to uncover new molecular mechanisms behind Alzheimer's, which could lead to better diagnostic tools and treatments.
Alzheimer's Diseaseenhancer RNAsgene regulationnoncoding RNAepigeneticsdisease pathologymethylationribonucleoprotein complexesneurodegenerationbrain function
Research Aims
3AIM 01Identify deregulated enhancer RNAs in human samples and iPSC-derived neurons and microglia.
AIM 02Explore the molecular mechanisms of eRNA functions and their protein interactions in AD pathology.
AIM 03Examine the eRNA methylome in response to Alzheimer's-associated signaling.
Skills the Lab Values
cell cultureRNA sequencingChIP-seqmicroglia isolationCRISPRfluorescent in situ hybridizationbioinformaticsinduced pluripotent stem cell (iPSC) technologyprotein interaction assayschromatin conformation capture
Output against the department
Publications201top 41% of dept.162nd of 402
this lab
most publishedleast published
Citations9.9ktop 49% of dept.197th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.