University of California-Los Angeles · NeuroscienceStem Cell Aging Research Lab
Thomas A. Rando · Los Angeles, California
Research Focus
Dr. Thomas A. Rando's lab at UCLA focuses on understanding how aging affects stem cells and exploring ways to enhance their function. They investigate the molecular changes that occur in stem cells over time and how these changes contribute to age-related declines in tissue repair and homeostasis. The research aims to develop interventions that can rejuvenate aged stem cells, which may lead to better therapeutic strategies for health issues in the elderly.
stem cell agingtissue repairage-related changesepigeneticsmetabolic changesstem cell heterogeneityrejuvenationbiological agingstem cell functiontherapeutics
Research Aims
5AIM 01Investigate how aging affects the molecular function of stem cells.
AIM 02Explore systemic factors that influence stem cell aging.
AIM 03Develop strategies to restore youthful properties to aged stem cells.
AIM 04Examine the role of epigenetic changes in stem cell function with age.
AIM 05Assess the impact of rejuvenating interventions on tissue repair.
Skills the Lab Values
CRISPR/Cas technologyflow cytometrysingle-cell proteomicsbioinformatics analysisspatial transcriptomicscell culturemolecular analysisgenetic screeningdata visualizationproteomics
Output against the department
Publications300top 22% of dept.149th of 671
this lab
most publishedleast published
Citations48ktop 7% of dept.47th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.