Johns Hopkins University · PhysiologyLutsenko Lab
Svetlana Lutsenko · Baltimore, Maryland
Research Focus
Dr. Svetlana Lutsenko's lab focuses on understanding how copper transport in the body relates to nutrient absorption and liver function, particularly in the context of Wilson disease, a serious genetic disorder. The lab investigates the molecular mechanisms behind copper's role in fat absorption and how disruptions in copper homeostasis can lead to metabolic disorders. By studying the interactions between different cell types and the effects of copper on nutrient transport, the lab aims to find new therapeutic strategies for managing Wilson disease and improving gastrointestinal health.
copper transportnutrient absorptionWilson diseasemetabolismintestinal health
Research Aims
3AIM 01Investigate the role of copper transporters in nutrient absorption and chylomicron secretion.
AIM 02Explore the biochemical interactions between copper and fatty acids in the intestine.
AIM 03Characterize how copper imbalance affects the metabolic profiles of patients with Wilson disease.
Skills the Lab Values
cell culturemouse modelssingle cell sequencingimmunostainingquantitative PCR (qPCR)
Output against the department
Publications207top 31% of dept.90th of 286
this lab
most publishedleast published
Citations20ktop 12% of dept.35th of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.