University of Minnesota-Twin Cities · BiologyThe Persistent HIV Lab
Kathleen A. Boris-Lawrie · Minneapolis, Minnesota
Research Focus
Dr. Kathleen A. Boris-Lawrie's lab focuses on understanding how HIV-1 persistently impacts the immune system even when viral loads are controlled through medication. They investigate the role of RNA modifications in HIV-1's ability to replicate and evade immune response. The lab aims to uncover new mechanisms behind HIV behavior, with the hope of informing future treatments to better address chronic HIV infections.
HIV-1RNA modificationsimmune signalingepigeneticsviral replicationdrug resistancepost-transcriptional regulationmethylation
Research Aims
5AIM 01Investigate the hypermethylation of HIV-1 RNA and its effects on viral gene expression.
AIM 02Explore the role of HIV-1 RNA structures in modulating immune signaling.
AIM 03Develop a structural understanding of viral RNA interactions with host proteins.
AIM 04Assess how dysregulation of the HIV cap modification influences immune responses.
AIM 05Identify potential therapeutic approaches targeting HIV-1's unique RNA modifications.
Skills the Lab Values
RNA sequencingcryoelectron microscopyRNA helicase A assayscell culturevirus isolation techniquesmolecular cloningdrug testing in vitroflow cytometry
Output against the department
Publications73bottom 21% of dept.817th of 1,033
this lab
most publishedleast published
Citations2.5kbottom 18% of dept.846th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.