RUThe Rockefeller University · Biology
Viral Pathogen Response Lab
Michael P Rout · New York, New York
Research Focus
Michael P Rout's lab at Rockefeller University focuses on innovative solutions to combat viral pandemics and understand important cellular structures called nuclear pore complexes. They develop advanced nanobodies from llamas to neutralize and treat infections caused by dangerous viruses like SARS-CoV-2, enhancing our preparedness for future outbreaks. Additionally, the lab investigates the structure and function of nuclear pore complexes to better understand their critical roles in gene regulation and cell function, aiming to uncover potential therapeutic targets for various diseases.
nanobodiespandemic preparednessSARS-CoV-2nuclear pore complexesviral infectionsgene expressionantiviral therapymolecular architecturecellular transport
Research Aims
5AIM 01Develop a comprehensive repertoire of nanobodies for neutralizing coronavirus variants.
AIM 02Optimize properties of nanobodies for effective therapeutic use in humans.
AIM 03Map the structural changes of nuclear pore complexes during their functional states.
AIM 04Investigate the mechanisms of mRNA export mediated by nuclear pore complexes.
AIM 05Explore the role of nuclear pore complexes in regulating gene expression epigenetically.
Skills the Lab Values
nanobody engineeringstructural biology techniquesin vivo testingcell culturemolecular cloningbiochemical assaysprotein purificationmicroscopybioinformatics
Output against the department
Publications487top 9% of dept.89th of 1,033
this lab
most publishedleast published
Citations22ktop 18% of dept.181st of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.