University of Southern California · Microbiology & ImmunologyHIV Gene Therapy Innovations Unit
Paula M Cannon · Los Angeles, California
Research Focus
Dr. Paula M. Cannon's lab focuses on developing innovative gene and cell therapy strategies to create a cure for HIV. The team emphasizes making these treatments safe, effective, and accessible, especially for people living with HIV in low and middle-income countries. They work on advanced techniques involving gene editing tools, stem cell manipulation, and novel delivery methods to enhance the efficacy of HIV therapies.
HIV curegene therapygene editingcell therapystem cells
Research Aims
4AIM 01Identify an optimal strategy to select for engineered hematopoietic stem cells and deplete the HIV reservoir.
AIM 02Identify the best vector approaches for in vivo engineering of hematopoietic stem cells and B cells.
AIM 03Evaluate the use of a novel organoid for in situ delivery of anti-HIV vectors.
AIM 04Identify the best combination of anti-HIV approaches based on CCR5 knockout expression of broadly acting HIV inhibitors.
Skills the Lab Values
in vivo cell engineeringgene delivery techniqueslentiviral vector designorganoid cultureCRISPR/Cas9flow cytometrycell isolation and characterizationdrug formulationB-cell manipulationstem cell differentiation
Output against the department
Publications126bottom 48% of dept.254th of 486
this lab
most publishedleast published
Citations6.9kbottom 49% of dept.248th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.