Stanford University · BiologyChen Neuroscience Lab
Xiaoke Chen · Stanford, California
Research Focus
Xiaoke Chen's lab at Stanford University focuses on understanding the biological mechanisms of opioid addiction, particularly how certain brain pathways influence withdrawal symptoms and relapse. By studying specific neuron groups in the brain, the lab aims to identify potential new targets for addiction treatment. Their work combines advanced technologies to visualize and analyze cells, which could lead to significant improvements in drug addiction therapies.
opioid addictionneurosciencesingle cell transcriptomicsepigenomicsdrug withdrawalbrain pathwaysneuron typesrelapse preventioncell profilingaddiction treatment
Research Aims
5AIM 01Identify opioid-responsive cell types in the paraventricular nucleus of thalamus and nucleus accumbens.
AIM 02Establish a spatially resolved single cell atlas of these brain regions.
AIM 03Determine how opioid-induced gene expression changes affect behavior during addiction and withdrawal.
AIM 04Investigate the anatomical connections between the neuron subgroups in related brain pathways.
AIM 05Explore novel molecular targets for treating opioid addiction.
Skills the Lab Values
single-cell RNA sequencingepigenomic profilingspatial imaging techniquescell cultureanimal modelsdata analysis using R/Pythonbehavioral assaysmolecular cloninggene manipulation3D imaging
Output against the department
Publications69bottom 19% of dept.836th of 1,033
this lab
most publishedleast published
Citations4.0kbottom 30% of dept.718th of 1,033
this lab
most citedleast cited
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