Duke University · Biomedical EngineeringRadiation Effects and Tissue Response Lab
Chang-Lung Lee · Durham, North Carolina
Research Focus
Dr. Chang-Lung Lee's lab at Duke University focuses on understanding how radiation therapy affects tissues, particularly in the context of head and neck cancer. One of their main projects aims to reduce the harmful side effects of radiation on oral tissue, specifically oral mucositis, by exploring the protective role of the p53 protein. The lab also investigates potential biomarkers for heart disease that could emerge following radiation exposure, which is crucial for identifying at-risk individuals after nuclear incidents.
radiation therapyoral mucositisp53 proteinhead and neck cancerbiomarkerscardiac dysfunctionacute radiation syndromeN-cadherintherapeutic strategiesfibroblasts
Research Aims
5AIM 01Investigate the role of p53 in regulating tissue repair following radiation exposure.
AIM 02Develop Mdm2 inhibitors to protect normal oral epithelium during radiation therapy.
AIM 03Identify serum pro-N-cadherin as a biomarker for radiation-induced heart disease.
AIM 04Evaluate the effectiveness of potential radioprotectors in genetic mouse models.
AIM 05Understand the mechanisms of cardiac remodeling after radiation exposure.
Skills the Lab Values
PCRanimal modelsimmunohistochemistrycell culturebiomarker analysisgenetic engineeringradiation exposure assessmentWestern blotbioinformaticsflow cytometry
Output against the department
Publications157bottom 34% of dept.387th of 595
this lab
most publishedleast published
Citations2.0kbottom 14% of dept.513th of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.