University of Pennsylvania · BiologyCancer Immunology and Genomic Stability Lab
Roger A Greenberg · Philadelphia, Pennsylvania
Research Focus
Dr. Roger A Greenberg's lab at the University of Pennsylvania focuses on understanding how cancer cells with genomic instability can stimulate immune responses. They study the interactions between damaged DNA in cancer cells and the immune system, which can affect tumor growth and immune therapy effectiveness. The lab employs a multidisciplinary approach, integrating various techniques to explore these relationships and develop new therapies for cancer.
genomic instabilityimmune responseDNA damagecancer immunotherapytumor microenvironmentpattern recognition receptorschromosome segregationin vivo studies
Research Aims
3AIM 01Investigate how DNA damage affects immune system recognition of cancer cells.
AIM 02Explore the effects of tissue architecture on chromosomal stability.
AIM 03Develop strategies to enhance immune activation against tumors.
Skills the Lab Values
cell cultureDNA damage assaysflow cytometryanimal modelingRNA extractionimmunofluorescencegenome sequencingbiophysical analysismicroscopy
Output against the department
Publications230top 27% of dept.275th of 1,033
this lab
most publishedleast published
Citations15ktop 25% of dept.255th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.