Pennsylvania State University-Main Campus · Biomedical EngineeringPritchard Lab
Justin Pritchard · University Park, Pennsylvania
Research Focus
Dr. Justin Pritchard's lab at Penn State focuses on studying tyrosine kinases, which are important proteins involved in many human diseases, including cancer. By combining experimental and computational techniques, the lab aims to understand how genetic variations in these proteins influence their function and responses to drugs. This research could lead to better predictions of disease risk and treatment outcomes for patients.
tyrosine kinasesdrug resistancegenetic variationCRISPRphylogeneticsmutational analysisepistasisbase editingprotein modelinggenotype-phenotype relationship
Research Aims
3AIM 01Generate mutational scanning data across diverse tyrosine kinases to assess the impact of genetic variations.
AIM 02Benchmark CRISPR Cas9 base editors for variant annotation in tyrosine kinases.
AIM 03Investigate epistatic interactions within kinase super-families and validate predictions through experiments.
Skills the Lab Values
CRISPRmutagenesisdata modelingvariant annotationbiostatisticsprotein structure analysiscell culturemedium throughput experimentationphylogenetic analysisnext-generation sequencing
Output against the department
Publications145bottom 31% of dept.410th of 595
this lab
most publishedleast published
Citations3.0kbottom 22% of dept.462nd of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.