George Washington University · Microbiology & ImmunologyChiappinelli Lab
Katherine B Chiappinelli · Washington, District of Columbia
Research Focus
Katherine B Chiappinelli's lab at George Washington University explores how certain genetic elements called LINE-1 contribute to immune evasion in ovarian cancer. They focus on understanding the mechanisms behind the expression of these elements and their effects on the tumor microenvironment. The long-term goal of this research is to uncover new potential therapies for ovarian cancer that target these immune evasion mechanisms.
ovarian cancerLINE-1immune evasionepigeneticstumor microenvironment
Research Aims
3AIM 01Determine effects of LINE-1 expression on innate immune signaling.
AIM 02Investigate how LINE-1 retrotransposition affects immune responses.
AIM 03Analyze the impact of LINE-1 expression on the ovarian cancer immune microenvironment.
Skills the Lab Values
DNA methylation analysiscell culturePCRtranscriptional regulation assaysgenome-wide profilingoncogene transformationimmunohistochemistryanimal models of cancerflow cytometry
Output against the department
Publications291top 17% of dept.84th of 486
this lab
most publishedleast published
Citations7.2ktop 49% of dept.238th of 486
this lab
most citedleast cited
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