University of Maryland, Baltimore · Microbiology & ImmunologyRahman Pathogen Lab
Mohammed Sayeedur Rahman · Baltimore, Maryland
Research Focus
Dr. Mohammed Sayeedur Rahman's lab at the University of Maryland Baltimore focuses on understanding how Rickettsia bacteria invade and survive within human cells. These bacteria can cause serious diseases, so the lab aims to uncover their strategies for manipulating the immune response to enhance their survival. By studying these interactions, the lab hopes to identify new approaches for preventing and treating rickettsial infections.
Rickettsiamacrophage polarizationinflammasome signalingautophagypathogen survivalintracellular bacteriaimmune responseinfectious diseaseshost-pathogen interactionsanti-virulence strategies
Research Aims
5AIM 01Define the mechanisms through which Rickettsia manipulate autophagy to enhance their survival.
AIM 02Investigate how Rickettsia suppress inflammasome activation to evade the immune response.
AIM 03Determine the effects of Rickettsia secreted effectors on macrophage polarization.
AIM 04Uncover the relationship between Rickettsia pathogenicity and host cell manipulation.
AIM 05Identify potential targets for anti-virulence strategies against Rickettsial infections.
Skills the Lab Values
cell culturemacrophage assaysPCRimmunofluorescence microscopyWestern blotcytokine assaysRNA extractionautophagy analysispathogen-host interaction studiesanimal models of infection
Output against the department
Publications10bottom 2% of dept.475th of 486
this lab
most publishedleast published
Citations214bottom 2% of dept.474th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.