Northwestern University · BiologyDombeck Lab
Daniel A Dombeck · Evanston, Illinois
Research Focus
Daniel A Dombeck's lab at Northwestern University focuses on understanding how neurons adapt and change in response to various stimuli, which is crucial for learning and memory. They use advanced imaging techniques to observe how changes in brain signals occur in real-time, helping to clarify how our brains function during behaviors like spatial navigation. Their work has important implications for treating conditions related to brain plasticity, such as addiction and chronic pain.
neural plasticitybrain imagingFRET/FLIM sensorssynaptic plasticitycalcium signalingbehavioral analysisneurosciencemolecular mechanismsgenetic toolsprotein engineering
Research Aims
3AIM 01Develop highly sensitive red-emitting FRET/FLIM sensors using protein libraries.
AIM 02Validate sensors ex vivo and in vivo for studying neuronal plasticity.
AIM 03Investigate synaptic and neuronal plasticity during spatial navigation tasks in awake mice.
Skills the Lab Values
multiplex imagingFRET (Fluorescence Resonance Energy Transfer)FLIM (Fluorescence Lifetime Imaging Microscopy)calcium imagingmouse modelsmolecular cloningprotein engineeringbehavioral experimentsdata analysis with MATLABin vivo imaging
Output against the department
Publications76bottom 22% of dept.806th of 1,033
this lab
most publishedleast published
Citations9.0ktop 42% of dept.436th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.