Yale University · Microbiology & ImmunologyBacterial Protein Regulation Lab
Eduardo Groisman · New Haven, Connecticut
Research Focus
Dr. Eduardo Groisman's lab at Yale University studies how bacteria manage their proteins to survive and cause disease. They focus on the mechanisms bacteria use to control protein levels and how this affects their ability to infect hosts and resist antibiotics. Their research has important implications for understanding bacterial infections and developing new treatment strategies.
bacterial virulenceproteolysisprotein homeostasisDnaKSalmonellaantibiotic resistanceprotein synthesismacrophage survivalmolecular chaperones
Research Aims
5AIM 01Investigate how proteolysis contributes to bacterial virulence mechanisms.
AIM 02Determine the role of the DnaK chaperone under stress conditions.
AIM 03Identify signals regulating protein expression during bacterial infection.
AIM 04Examine how proteases influence the expression of virulence genes.
AIM 05Explore the impact of protein degradation on bacterial survival in macrophages.
Skills the Lab Values
PCRbacterial culturegenetic manipulationprotein purificationbiochemical assaysmicrobiological techniquesribosome profilingmass spectrometryWestern blotmicroscopy
Output against the department
Publications225top 28% of dept.134th of 486
this lab
most publishedleast published
Citations27ktop 13% of dept.61st of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.