University of North Carolina at Chapel Hill · BiochemistryThe HIV Reservoir Initiative
Guochun Jiang · Chapel Hill, North Carolina
Research Focus
Dr. Guochun Jiang's lab at UNC Chapel Hill focuses on understanding HIV latency and the molecular mechanisms that control HIV reservoirs in the brain. Their research investigates how specific epigenetic modifications influence the behavior of HIV, particularly in myeloid cells in the central nervous system. By developing new therapeutic strategies, the lab aims to find ways to disrupt HIV latency and enhance treatment effectiveness for individuals living with HIV.
HIV latencyepigenetic regulationhistone modificationsmyeloid cellstherapeutic strategiesHIV reservoirsdecrotonylationCNSantiretroviral therapyHIV cure
Research Aims
3AIM 01Investigate how crotonylation differs from acetylation in regulating HIV transcription.
AIM 02Define the role of decrotonylation in controlling HIV latency.
AIM 03Examine pharmacological approaches to modulate decrotonylation and prevent HIV latency establishment.
Skills the Lab Values
cell cultureRNA sequencingflow cytometryCRISPRbioinformaticssingle-cell techniquesgenome amplificationpharmacologic modulationin vitro infection assaysviral genotyping
Output against the department
Publications75bottom 14% of dept.345th of 402
this lab
most publishedleast published
Citations2.6kbottom 12% of dept.353rd of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.