Brown University · BiologyCardiorenal Aging Research Group
Marc Tatar · Providence, Rhode Island
Research Focus
Dr. Marc Tatar's lab at Brown University explores how aging affects the communication between the kidney, adrenal glands, and heart. They focus on understanding a condition known as cardiorenal syndrome, where dysfunction in one organ can lead to problems in others, particularly in older adults. Through transplant experiments in mice, the lab examines how these interactions may promote fibrosis and contribute to age-related organ decline.
cardiorenal syndromeaginginterorgan communicationfibrosiskidney transplantadrenal glandsheart dysfunctionDrosophila modelingextracellular matrix
Research Aims
4AIM 01Investigate how aging alters organ communication between the kidney, adrenal glands, and heart.
AIM 02Identify mechanisms by which organ dysfunction leads to fibrosis in aged individuals.
AIM 03Utilize mouse and Drosophila models to study the effects of organ transplantation on cardiac health.
AIM 04Examine the role of renal hormones in mediating interorgan communication and its impact on aging.
Skills the Lab Values
mouse modelstissue transplantationexperimental designfibrosis assessmentprotein analysiscell cultureRNA isolationWestern blottingDrosophila genetics
Output against the department
Publications155top 44% of dept.449th of 1,033
this lab
most publishedleast published
Citations23ktop 17% of dept.174th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.