University of Pennsylvania · BiologyPlasma Cell Survival Laboratory
David M Allman · Philadelphia, Pennsylvania
Research Focus
David M Allman's lab at the University of Pennsylvania focuses on understanding the survival mechanisms of plasma cells, which are crucial for producing antibodies in the immune system. They study how these cells adapt to their environments and resist therapies, particularly in diseases like multiple myeloma and during organ transplantation. The lab utilizes advanced techniques to explore the molecular pathways involved in plasma cell longevity and how they can be targeted for therapeutic interventions.
plasma cellshumoral immunitymultiple myelomapurinergic receptorsproteasome inhibitorscell survivalextracellular ATPantibody secretionbone marrowimmunotherapy
Research Aims
5AIM 01Investigate how purinergic receptors regulate the survival of long-lived plasma cells.
AIM 02Identify mechanisms that contribute to drug resistance in myeloma cells.
AIM 03Develop strategies to target and deplete pathogenic plasma cells in autoimmunity and transplantation.
AIM 04Examine the role of extracellular ATP in the maintenance of plasma cell functionality.
AIM 05Explore the biochemical pathways that lead to plasma cell malignancy in multiple myeloma.
Skills the Lab Values
cell culturemouse modelsimmunofluorescencePCRWestern blottingdrug testing on cell linesflow cytometrypatient-derived xenograft modelsgene expression analysismolecular cloning
Output against the department
Publications194top 33% of dept.340th of 1,033
this lab
most publishedleast published
Citations18ktop 23% of dept.233rd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.