University of Chicago · Biomedical EngineeringHuang Lab
Jun Huang · Chicago, Illinois
Research Focus
Jun Huang's lab at the University of Chicago focuses on developing innovative treatments for Alzheimer's Disease (AD) using advanced biotechnology. The lab is exploring how to engineer microglia, the brain's immune cells, to more effectively clear harmful amyloid-beta plaques associated with AD. Their work aims to create microglia that can recognize and degrade these plaques to help slow the disease's progression.
Alzheimer's DiseaseCAR-Microgliaamyloid-betamicroglialipid nanoparticlesgene therapyneuroinflammationimmunologyCNS
Research Aims
5AIM 01Develop CAR constructs that target amyloid-beta plaques in microglia.
AIM 02Package mRNA for CARs in lipid nanoparticles to promote microglial uptake.
AIM 03Test the effectiveness of CAR-transfected microglia in 5XFAD mouse models.
AIM 04Reduce amyloid-beta plaque levels and neuroinflammation in vivo.
AIM 05Create a more supportive microenvironment in the brain for treating Alzheimer's.
Skills the Lab Values
cell cultureCRISPRRNA transfectionlipid nanoparticle technologymouse modelsflow cytometryimmunohistochemistrymolecular cloningprotein engineering
Output against the department
Publications696top 9% of dept.51st of 595
this lab
most publishedleast published
Citations36ktop 6% of dept.36th of 595
this lab
most citedleast cited
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