University of Alabama at Birmingham · BiologyWnt Signaling and Skeletal Development Lab
Jianbo Wang · Birmingham, Alabama
Research Focus
Dr. Jianbo Wang's lab at the University of Alabama at Birmingham focuses on understanding how a specific signaling molecule, Wnt5a, contributes to skeletal development and its associated disorders. They explore the molecular mechanisms of skeletal formation, particularly how mutations in the WNT5A gene lead to congenital skeletal diseases like Robinow syndrome. The lab uses various biochemical and genetic techniques to develop insights that could ultimately aid in regenerative medicine and therapies for skeletal disorders.
Wnt signalingskeletal developmentcongenital disordersRobinow syndromeregenerative medicine
Research Aims
3AIM 01Investigate how different isoforms of Wnt5a affect limb development.
AIM 02Characterize the structural basis of Wnt5a signaling through receptor interactions.
AIM 03Determine the impact of ADRS mutations on Wnt5a activity and skeletal formation.
Skills the Lab Values
mouse modelsbiochemical assaysmolecular cloningprotein expressionflow cytometry
Output against the department
Publications735top 3% of dept.28th of 1,033
this lab
most publishedleast published
Citations29ktop 12% of dept.120th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.