Wayne State University · ChemistryThe Protein Dynamics Lab
Mary Kay H Pflum · Detroit, Michigan
Research Focus
Dr. Mary Kay Pflum's lab at Wayne State University focuses on understanding how modifications to proteins, such as phosphorylation and acetylation, influence their function and interactions in cells. These modifications are crucial for many cellular processes and are linked to diseases like cancer. The lab develops innovative chemical tools to study these protein changes, which could help in discovering new disease mechanisms and treatments.
protein modificationsphosphorylationacetylationkinasesHDAC enzymescell biologydrug designepigenetics
Research Aims
5AIM 01Develop new methods to study kinase and phosphatase interactions with their substrates.
AIM 02Investigate the roles of HDAC proteins beyond their known epigenetic functions.
AIM 03Expand trapping strategies to study the interactions of demethylase enzymes.
AIM 04Collaborate with biologists to apply chemical tools to various biological problems.
AIM 05Enhance understanding of disease mechanisms linked to protein modifications.
Skills the Lab Values
protein purificationcell cultureenzyme assaysmass spectrometryfluorescent labelingchemical synthesisWestern blotPCRmicroscopy
Output against the department
Publications83bottom 17% of dept.179th of 216
this lab
most publishedleast published
Citations1.8kbottom 13% of dept.189th of 216
this lab
most citedleast cited
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