University of Colorado Denver/Anschutz Medical Campus · Pharmacology

Costello Genomics Lab

James Christopher Costello · Denver, Colorado

Research Focus

Dr. James Christopher Costello's lab at the University of Colorado Denver focuses on understanding Down syndrome by examining how the genes on chromosome 21 influence various co-occurring health conditions. The lab uses innovative computational techniques, particularly in 'omics' data analysis, to find specific signals related to these diseases. Their work aims to improve care not only for individuals with Down syndrome but also for the broader community.

Down syndromemulti-omicscomputational biologyneural networksgenomic analysisdata coordinationcomplex diseasemachine learningknowledge graphs

Research Aims

AIM 01Develop methods to identify shared genetic mechanisms between Down syndrome and other complex diseases.

AIM 02Create methodologies to distinguish generic from context-specific signals in multi-omic datasets.

AIM 03Investigate molecular connections between chromosome 21 genes and various co-occurring conditions.

Skills the Lab Values

genomic data analysistranscriptomic dataset evaluationneural network modelingknowledge graph constructiondifferential expression analysisPython programmingdata visualizationmachine learning techniquesbioinformatics

Costello Genomics Lab

Research Focus

Research Aims

Skills the Lab Values

Output against the department