Columbia University in the City of New York · GeneticsHematopoiesis Haven
Emmanuelle Passegue · New York, New York
Research Focus
Dr. Emmanuelle Passegue's lab at Columbia University focuses on understanding how blood cells develop and how their production can go awry in diseases like leukemia and during aging. The research involves investigating how special blood-forming cells adapt to challenges and stressors, which can lead to various blood disorders. By studying these processes, the lab aims to uncover new strategies for improving treatments for blood-related diseases.
HematopoiesisMyelopoiesisAgingLeukemiaBone MarrowStem CellsImmune SystemTranscriptional RegulationEpigenetics
Research Aims
5AIM 01Investigate the mechanisms of emergency myelopoiesis in blood production
AIM 02Study the role of emergency myelopoiesis in myeloid malignancies
AIM 03Explore how aging affects hematopoietic stem cell function
AIM 04Develop models to simulate blood cell environments
AIM 05Identify therapeutic targets for blood disorders and solid cancers.
Skills the Lab Values
Cell cultureSingle-cell RNA sequencingFlow cytometryWestern blottingTranscriptional profilingCRISPRMetabolic assaysMouse modelsSpatial imaging techniques
Output against the department
Publications184top 45% of dept.117th of 259
this lab
most publishedleast published
Citations22ktop 27% of dept.71st of 259
this lab
most citedleast cited
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