Johns Hopkins University · NeuroscienceBergles Myelin Lab
Dwight E Bergles · Baltimore, Maryland
Research Focus
Dr. Dwight E. Bergles' lab at Johns Hopkins University focuses on understanding a specific type of brain cell called oligodendrocyte precursor cells (OPCs). These cells play critical roles in maintaining and repairing the brain's myelin, which is essential for proper neural signaling. The lab is developing advanced tools to study how these cells respond to aging and diseases like Alzheimer's, aiming to uncover their potential in promoting brain health and regeneration.
oligodendrocyte precursor cellsAlzheimer's diseasemyelin repairglial cellsneuroinflammationAAV vectors
Research Aims
5AIM 01Develop AAV vectors that specifically target oligodendrocyte precursor cells.
AIM 02Investigate how OPCs behave in response to Alzheimer's disease pathology.
AIM 03Explore the role of OPCs in myelin regeneration during aging.
AIM 04Analyze glutamate signaling interactions between OPCs and neurons.
AIM 05Understand the impact of OPCs on neuroinflammation and neural health.
Skills the Lab Values
PCRcell culturemouse modelstwo-photon imaginggenetic manipulationviral vector designhistologyWestern blotRNA sequencing
Output against the department
Publications201top 37% of dept.246th of 671
this lab
most publishedleast published
Citations27ktop 14% of dept.97th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.