Yale University · ChemistryMiller Catalysis Lab
Scott J Miller · New Haven, Connecticut
Research Focus
Scott J Miller's lab at Yale University focuses on developing new catalysts and chemical reactions to modify complex bioactive molecules, which are essential in drug discovery. The research aims to create efficient methods for synthesizing and diversifying drug candidates by targeting specific functional groups in these molecules. Overall, their work is poised to significantly advance the field of medicinal chemistry, particularly in creating novel therapeutics.
site-selective catalysisbioactive scaffoldsenantioselectivitycatalyst librariesredox reactionsglycosylationdrug synthesiscomplex moleculesmedicinal chemistry
Research Aims
5AIM 01Develop new catalysts for site-selective modifications of complex bioactive molecules.
AIM 02Investigate reaction mechanisms to improve the understanding of catalysis in medicinal chemistry.
AIM 03Synthesize analogs of natural products to explore new drug candidates.
AIM 04Expand the study of stereochemical issues related to drug synthesis and development.
AIM 05Create efficient methods for the functionalization of therapeutic scaffolds.
Skills the Lab Values
catalyst developmentsite-selective functionalizationorganic synthesisreaction mechanism analysisphotochemical reactionselectrochemical techniquesglycosylation methodsstereochemistry techniqueschemical library generation
Output against the department
Publications782top 7% of dept.16th of 216
this lab
most publishedleast published
Citations23ktop 21% of dept.45th of 216
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.